Recombinant Human IMPase2 (N-6His)

Product Specifications

Background

Inositol monophosphatase 2, also known as Inositol-1 (or 4) -monophosphatase 2, Myo-inositol monophosphatase A2 and IMPA2, is an enzyme which belongs to the inositol monophosphatase family. IMPA2 catalyzes the dephosphoylration of inositol monophosphate with cofactor Magnesium and Inhibited by high Li+ and restricted Mg2+ concentrations. IMPA2 plays an important role in phosphatidylinositol signaling. IMPA2 can use the myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. IMPA2 is a pharmacological target for lithium Li (+) action in brain, it is considered to have a role in schizophrenia and bipolar disorder.

Product Name Alternative

Inositol Monophosphatase 2; IMP 2; IMPase 2; Inositol-1 (or 4) -Monophosphatase 2; Myo-Inositol Monophosphatase A2; IMPA2; IMP.18P

Accession Number

O14732

Host

E.coli

Endotoxin

<1 EU/µg as determined by LAL test.

Purity

Greater than 95% as determined by reducing SDS-PAGE

Form

Liquid

Molecular Weight

33.5 KDa

Shipping Conditions

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

Storage Conditions

Store at -70°C/-20°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 2mM DTT, pH 8.0.

Construct

Recombinant Human Inositol Monophosphatase 2 is produced by our E.coli expression system and the target gene encoding Met1-Lys288 is expressed with a 6His tag at the N-terminus.