PARP-2-IN-1

PARP-2-IN-1 is a potent and selective PARP-2 inhibitor with an IC50 of 11.5 nM.

Product Specifications

CAS Number

[2115698-83-2]

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PARP-2-IN-1.html

Purity

99.56

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC(CN2C(NC(C3=C2C=CC=C3)=O)=O)=CN=C1F)[C@H]4CCN(CC(F)(F)F)C4

Molecular Formula

C21H19F4N5O3

Molecular Weight

465.40

References & Citations

[1]Zhao H, et al. Discovery of novel quinazoline-2,4 (1H,3H) -dione derivatives as potent PARP-2 selective inhibitors. Bioorg Med Chem. 2017 Aug 1;25 (15) :4045-4054.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PARP2

Available Sizes

Curated Selection

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