PARP-2-IN-1
PARP-2-IN-1 is a potent and selective PARP-2 inhibitor with an IC50 of 11.5 nM.
Product Specifications
CAS Number
[2115698-83-2]
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PARP-2-IN-1.html
Purity
99.56
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(CN2C(NC(C3=C2C=CC=C3)=O)=O)=CN=C1F)[C@H]4CCN(CC(F)(F)F)C4
Molecular Formula
C21H19F4N5O3
Molecular Weight
465.40
References & Citations
[1]Zhao H, et al. Discovery of novel quinazoline-2,4 (1H,3H) -dione derivatives as potent PARP-2 selective inhibitors. Bioorg Med Chem. 2017 Aug 1;25 (15) :4045-4054.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP2
Available Sizes
Curated Selection
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