Groenlandicine
Product Specifications
UNSPSC Description
Groenlandicine is a protoberberine alkaloid isolated from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR)[1]. Groenlandicine selectively induces topoisomerase I-mediated DNA cleavage[2].
Target Antigen
Topoisomerase
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/groenlandicine.html
Purity
99.87
Solubility
DMSO : 1 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
COC1=CC2=C(C=C1O)CC[N+]3=CC4=C(C=CC5=C4OCO5)C=C23
Molecular Weight
322.34
References & Citations
[1]Jung HA, et al. Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase. Arch Pharm Res. 2008 Nov;31(11):1405-12.|[2]Kobayashi Y, et al. Inhibitors of DNA topoisomerase I and II isolated from the Coptis rhizomes. Planta Med. 1995 Oct;61(5):414-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N6865/Groenlandicine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N6865/Groenlandicine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
38691-95-1
Available Sizes
Curated Selection
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