Groenlandicine

Groenlandicine, a protoberberine alkaloid, is a cholinesterase inhibitor (AChE (IC50 = 0.54 μM), BChE (IC50 = 3.32 μM) ) . Groenlandicine non-competitively inhibits BACE1 (IC50 = 19.68 μM, Ki = 21.2) and inhibits RLAR (IC50 = 140.1 μM), HRAR (IC50 = 154.2 μM), and total ROS generation (IC50 = 51.78 μM) in vitro. Groenlandicine suppresses osteosarcoma cell proliferation while promoting apoptosis. Groenlandicine inhibits the tumor growth when combined with Cisplatin (HY-17394) . Groenlandicine can be used for the study on osteosarcoma, Alzheimer's disease and diabetes mellitus [1][2][3][4][5].

Product Specifications

CAS Number

[38691-95-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Beta-secretase; Cholinesterase (ChE) ; Reactive Oxygen Species (ROS) ; Topoisomerase

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Neurological Disease; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/groenlandicine.html

Purity

99.87

Solubility

DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=CC2=C(C=C1O)CC[N+]3=CC4=C(C=CC5=C4OCO5)C=C23

Molecular Formula

C19H16NO4+

Molecular Weight

322.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhao Z, et al. Groenlandicine enhances cisplatin sensitivity in cisplatin-resistant osteosarcoma cells through the BAX/Bcl-2/Caspase-9/Caspase-3 pathway. J Bone Oncol. 2024 Aug 24;48:100631. |[2]Jung HA, et al. Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids. Biol Pharm Bull. 2009 Aug;32 (8) :1433-8. |[3]Yokozawa T, et al. Protective role of Coptidis Rhizoma alkaloids against peroxynitrite-induced damage to renal tubular epithelial cells. J Pharm Pharmacol. 2005 Mar;57 (3) :367-74. |[4]Jung HA, et al. Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase. Arch Pharm Res. 2008 Nov;31 (11) :1405-12. |[5]Kobayashi Y, et al. Inhibitors of DNA topoisomerase I and II isolated from the Coptis rhizomes. Planta Med. 1995 Oct;61 (5) :414-8.