SHP1-IN-1
SHP1-IN-1 (compound 5p) is a fluorescent probe for the protein tyrosine phosphatase SHP1 containing the Src homology 2 domain. SHP1-IN-1 has SHP1 inhibitory activity, selectivity for Fe3+ ions and good fluorescence properties. SHP1-IN-1 exhibits aggregation post-quenching (ACQ) effect, good interference immunity and low detection limit (5.55 μM) [1].
Product Specifications
CAS Number
2956720-62-8
UNSPSC
12171500
Target
Fluorescent Dye; Phosphatase; SHP1
Type
Dye Reagents
Related Pathways
Metabolic Enzyme/Protease; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shp1-in-1.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=CC(C2=NC3=NC(C4=CC=C(C(C(O)=O)=C4)O)=C(N3N2)NC(C)(C)C)=C1
Molecular Formula
C22H23N5O4
Molecular Weight
421.45
References & Citations
[1]Yan X, et al. Novel imidazo[1,2,4] triazole derivatives: Synthesis, fluorescence, bioactivity for SHP1. Eur J Med Chem. 2024 Feb 5;265:116027.
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
