YGL-12
YGL-12 is a potent PPARγ modulator with good binding affinity and an IC50 value of 0.85 μM. YGL-12 effectively blocks PPARγ Ser273 phosphorylation and can be used in diabetes research[1].
Product Specifications
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ygl-12.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C2=CC=C(O)C=C2)SC3C1C=CC(O)=C3)C(C=C4)=CC=C4OCC5CCCCC5
Molecular Formula
C28H28O4S
Molecular Weight
460.58
References & Citations
[1]Liu Q, et al. Raloxifene-driven benzothiophene derivatives: Discovery, structural refinement, and biological evaluation as potent PPARγ modulators based on drug repurposing. Eur J Med Chem. 2024 Apr 5;269:116325.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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