Phleomycin
Phleomycin is a copper-dependent DNA damaging agent and antibiotic with antitumor activity. Phleomycin binds to DNA and produces ROS in the presence of reducing agents (such as dithiothreitol and glutathione), inducing single-strand and double-strand breaks in DNA. Phleomycin can induce cell apoptosis or mutation and is widely used in cancer inhibition, microbial genetic transformation (as a screening marker to improve fungal transformation efficiency) and DNA repair mechanism research[1][2][3].
Product Specifications
CAS Number
11006-33-0
UNSPSC
12352005
Hazard Statement
H302
Target
Antibiotic; Bacterial; DNA/RNA Synthesis
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/phleomycin.html
Purity
95.0
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
[Phleomycin]
Precautions
H302
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Glycopeptide
Available Sizes
Frequently Asked Questions
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