Phleomycin

Phleomycin is a copper-dependent DNA damaging agent and antibiotic with antitumor activity. Phleomycin binds to DNA and produces ROS in the presence of reducing agents (such as dithiothreitol and glutathione), inducing single-strand and double-strand breaks in DNA. Phleomycin can induce cell apoptosis or mutation and is widely used in cancer inhibition, microbial genetic transformation (as a screening marker to improve fungal transformation efficiency) and DNA repair mechanism research[1][2][3].

Product Specifications

CAS Number

[11006-33-0]

UNSPSC

12352005

Hazard Statement

H302

Target

Antibiotic; Bacterial; DNA/RNA Synthesis

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/phleomycin.html

Purity

95.0

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

[Phleomycin]

Precautions

H302

References & Citations

[1]Kamila Stokowa-Sołtys, et al. Phleomycin complex-Coordination mode and in vitro cleavage of DNA. J Inorg Biochem. 2019 Jun;195:71-82.|[2]van Peer AF, et al. Phleomycin increases transformation efficiency and promotes single integrations in Schizophyllum commune. Appl Environ Microbiol. 2009 Mar;75 (5) :1243-7.|[3]TANAKA N, et al. Mechanism of action of phleomycin, a tumor-inhibitory antibiotic. Biochem Biophys Res Commun. 1963 Jan 31;10:171-4.