XMU-MP-9
XMU-MP-9 is a bifunctional compound that binds to the C2 domain of Nedd4-1 and the allosteric site of K-Ras. XMU-MP-9 enhances the interaction between Nedd4-1 and K-Ras, induces conformational changes in the Nedd4-1/K-Ras complex, promotes the ubiquitination and degradation of multiple K-Ras mutants, and inhibits the proliferation of cells carrying K-Ras mutants. XMU-MP-9 can be used for the study of colon, lung and pancreatic cancer[1].
Product Specifications
CAS Number
[2251130-41-1]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xmu-mp-9.html
Purity
99.12
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
FC1=C(CNC(C2=CSC(C3=NNC4=CC=CC=C34)=C2)=O)C(Cl)=CC=C1
Molecular Formula
C19H13ClFN3OS
Molecular Weight
385.84
References & Citations
[1]Taoling Zeng, et al. "Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1." bioRxiv (2024) : 2024-04.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
SYNJ2 (Synaptojanin-2, Synaptic Inositol 1,4,5-trisphosphate 5-phosphatase 2, INPP5H, KIAA0348) (MaxLight 650)
