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XMU-MP-9

XMU-MP-9 is a bifunctional compound that binds to the C2 domain of Nedd4-1 and the allosteric site of K-Ras. XMU-MP-9 enhances the interaction between Nedd4-1 and K-Ras, induces conformational changes in the Nedd4-1/K-Ras complex, promotes the ubiquitination and degradation of multiple K-Ras mutants, and inhibits the proliferation of cells carrying K-Ras mutants. XMU-MP-9 can be used for the study of colon, lung and pancreatic cancer[1].

Product Specifications

CAS Number

[2251130-41-1]

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/xmu-mp-9.html

Purity

99.12

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

FC1=C(CNC(C2=CSC(C3=NNC4=CC=CC=C34)=C2)=O)C(Cl)=CC=C1

Molecular Formula

C19H13ClFN3OS

Molecular Weight

385.84

References & Citations

[1]Taoling Zeng, et al. "Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1." bioRxiv (2024) : 2024-04.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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