D-erythro-MAPP

D-erythro-MAPP (D-e-MAPP) is a ceramidase inhibitor, with an IC50 of 1-5 μM in vitro[1].

Product Specifications

CAS Number

[143492-38-0]

Product Name Alternative

D-e-MAPP

UNSPSC

12352005

Target

Ceramidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/d-erythro-mapp.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC(CCCCCCCCCCCCC)=O

Molecular Formula

C23H39NO2

Molecular Weight

361.56

References & Citations

[1]Hüseyin İzgördü, et al. Characteristics of apoptosis induction in human breast cancer cells treated with a ceramidase inhibitor. Cytotechnology. 2020 Dec;72 (6) :907-919.|[2]A Bielawska, et al. (1S,2R) -D-erythro-2- (N-myristoylamino) -1-phenyl-1-propanol as an inhibitor of ceramidase. J Biol Chem. 1996 May 24;271 (21) :12646-54.