Monoclonal Anti-MMAE specific Antibody, Rabbit IgG (M1G04)
Product Specifications
Background
Monomethyl auristatin E (MMAE) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several cancer types. Anti-MMAE antibody is a rabbit monoclonal antibody specially react with MMAE without MMAF, which is more sensitive than mouse antibody. The anti-MMAE antibody is a useful reagent in PK assay to determine conjugated antibodies.
Structure Composition
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Immunogen
MMAE-BSA
Conjugation
Unconjugated
Applications
ELISA
Dilution
ELISA 0.06-125 ng/mL
Purity
Protein A purified / Protein G purified
Modification
Unmodified
Storage Conditions
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Specifically recognizes MMAE and does not recognize MMAF.
Applications Notes
Immobilized Disitamab Vedotin (RC48) at 0.2 μg/mL (100 μL/well) can bind Monoclonal Anti-MMAE specific Antibody, Rabbit IgG (M1G04) with a linear range of 0.06-4 ng/mL (QC tested) .
Host or Source
Rabbit
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