Biotinylated Monoclonal Anti-MMAE&MMAF Antibody, Mouse IgG1
Product Specifications
Background
Monomethyl auristatin E (MMAE) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types. Anti-MMAE antibody is a Mouse monoclonal antibody. This antibody has been shown to work in applications such as: PK, PD, Immunoassay and ELISA.
Structure Composition
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Immunogen
MMAE
Conjugation
Unconjugated
Applications
ELISA
Dilution
ELISA 2-250 ng/mL
Purity
Protein A purified / Protein G purified
Modification
Biotinylated
Storage Conditions
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Specifically recognizes the target-MMAE&MMAF.
Applications Notes
Immobilized Disitamab Vedotin (RC48) at 1 μg/mL (100 μL/well) can bind Biotinylated Monoclonal Anti-MMAE&MMAF Antibody, Mouse IgG1 with a linear range of 2-31 ng/mL (QC tested) .
Host or Source
Mouse
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