GAB1 (Phospho-Y659) polyclonal antibody
Product Specifications
Background
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
GAB1; GRB2
Swiss Prot
Q13480
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic phosphorylated peptide around Y659 of human GAB1 (NP_002030.2) .
Conjugation
Unconjugated
Applications
WB
Dilution
WB,1:500 - 1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylation
Molecular Weight
110kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
GAB1 (Phospho-Y659) polyclonal antibody detects endogenous levels of GAB1 protein only when phosphorylated at Tyr659.
Applications Notes
Western blot analysis of GAB1 (Phospho-Y659) expression in HeLa insulin-treated (A), NIH3T3 (B), C6 (C), Raw264.7 insulin-treated (D), H9C2 insulin-treated (E) whole cell lysates.
Host or Source
Rabbit
Available Sizes
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