BMP-6 (A152) polyclonal antibody

Product Specifications

Background

In vivo studies have shown that BMP-2 (also designated BMP-2A) and BMP-3 can independently induce cartilage formation. Smad3 association with the TGFβ receptor complex and Smad1 translocation to the nucleus are ob_x0002_served after the addition of BMP-4 (also designated BMP-2B), suggesting that BMP-4 may play a role in ac_x0002_tivation of the Smad pathway. BMP-5, BMP-6 and BMP-7 all share high sequence homology with BMP-2, indicating that they each may be able to induce cartilage formation. BMP-8 (also designated OP-2) is thought to be involved in early development, as detectable expression has not been found in adult organs.

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Bone morphogenetic protein 6; BMP-6; VG-1-related protein (VG-1-R; VGR-1) ; BMP6; VGR

Swiss Prot

P22004

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human BMP-6.

Conjugation

Unconjugated

Applications

WB, IHC

Dilution

WB: 1:500~1:1000 IHC: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodified

Molecular Weight

~ 55-65 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

BMP-6 (A152) polyclonal antibody detects endogenous levels of BMP-6 protein.

Applications Notes

Western blot (WB) analysis of BMP-6 (A152) polyclonal antibody at 1:500 dilution Lane1:PC12 whole cell lysate (40ug) Lane2:3T3-L1 whole cell lysate (40ug) Lane3:U-87MG whole cell lysate (40ug) Lane4:A375 whole cell lysate (40ug)