Human BRD2 Bromodomain 2

<strong>Human BRD2 Bromodomain 2</strong>_x000D_ <strong>Catalog number:</strong> B2017230_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 42 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> Bromodomain containing protein 2, RING3, RNF3_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Yu Z, Ku AF, Anglin JL, Sharma R, Ucisik MN, Faver JC, Li F, Nyshadham P, Simmons N, Sharma KL, Nagarajan S, Riehle K, Kaur G, Sankaran B, Storl-Desmond M, Palmer SS, Young DW, Kim C, Matzuk MM. Discovery and characterization of bromodomain 2-specific inhibitors of BRDT Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2021102118._x000D_ 2: Greenwald RJ, Tumang JR, Sinha A, Currier N, Cardiff RD, Rothstein TL, Faller DV, Denis GV. E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia Blood. 2004 Feb 15;103(4):1475-84._x000D_ 3: Tian CQ, Chen L, Chen HD, Huan XJ, Hu JP, Shen JK, Xiong B, Wang YQ, Miao ZH. Inhibition of the BET family reduces its new target gene IDO1 expression and the production of L-kynurenine Cell Death Dis. 2019 Jul 19;10(8):557._x000D_ 4: Kang JH, Splinter PL, Trussoni CE, Pirius NE, Gores GJ, LaRusso NF, O'Hara SP. The Epigenetic Reader, Bromodomain Containing 2, Mediates Cholangiocyte Senescence via Interaction With ETS Proto-Oncogene 1 Gastroenterology. 2023 Jul;165(1):228-243.e2._x000D_ 5: Imaide S, Riching KM, Makukhin N, Vetma V, Whitworth C, Hughes SJ, Trainor N, Mahan SD, Murphy N, Cowan AD, Chan KH, Craigon C, Testa A, Maniaci C, Urh M, Daniels DL, Ciulli A. Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity Nat Chem Biol. 2021 Nov;17(11):1157-1167._x000D_ 6: Cribbs AP, Filippakopoulos P, Philpott M, Wells G, Penn H, Oerum H, Valge-Archer V, Feldmann M, Oppermann U. Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function Front Immunol. 2021 Feb 26;12:626255._x000D_ 7: Ji Y, Chen W, Wang X. Bromodomain and Extraterminal Domain Protein 2 in Multiple Human Diseases J Pharmacol Exp Ther. 2024 May 21;389(3):277-288._x000D_ 8: Zengerle M, Chan KH, Ciulli A. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4 ACS Chem Biol. 2015 Aug 21;10(8):1770-7._x000D_ 9: Yu Z, Ku AF, Anglin JL, Sharma R, Ucisik MN, Faver JC, Li F, Nyshadham P, Simmons N, Sharma KL, Nagarajan S, Riehle K, Kaur G, Sankaran B, Storl-Desmond M, Palmer SS, Young DW, Kim C, Matzuk MM. Discovery and characterization of bromodomain 2-specific inhibitors of BRDT Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2021102118._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/21189220">10: Denis GV. Bromodomain coactivators in cancer, obesity, type 2 diabetes, and inflammation Discov Med. 2010 Dec;10(55):489-99.</a>_x000D_ _x000D_ <strong>Products Related to Human BRD2 Bromodomain 2 can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>