AZD1080
AZD1080 is a potent and selective GSK3 inhibitor. AZD1080 inhibits recombinant human GSK3α and GSK3β with pKi (IC50) of 8.2 (6.9 nM) and 7.5 (31 nM), respectively.
Product Specifications
CAS Number
[612487-72-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/AZD1080.html
Purity
99.16
Solubility
DMSO : 21.35 mg/mL (ultrasonic; warming)
Smiles
OC(N1)=C(C2=CC=C(CN3CCOCC3)C=N2)C4=C1C=CC(C#N)=C4
Molecular Formula
C19H18N4O2
Molecular Weight
334.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Georgievska B, et al. AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. J Neurochem. 2013 May;125 (3) :446-56.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
GSK-3α; GSK-3β
Available Sizes
Curated Selection
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