AZD1080

AZD1080 is a potent and selective GSK3 inhibitor. AZD1080 inhibits recombinant human GSK3α and GSK3β with pKi (IC50) of 8.2 (6.9 nM) and 7.5 (31 nM), respectively.

Product Specifications

CAS Number

[612487-72-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GSK-3

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/AZD1080.html

Purity

99.16

Solubility

DMSO : 21.35 mg/mL (ultrasonic; warming)

Smiles

OC(N1)=C(C2=CC=C(CN3CCOCC3)C=N2)C4=C1C=CC(C#N)=C4

Molecular Formula

C19H18N4O2

Molecular Weight

334.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Georgievska B, et al. AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. J Neurochem. 2013 May;125 (3) :446-56.