4-Nitrophenyl-N-acetyl-β-D-glucosaminide

4-Nitrophenyl-N-acetyl-β-D-glucosaminide, an artificial substrate of N-acetyl-beta-D-hexosaminidase (NAGase), can be used in rapid and accurate rate assay for N-acetyl-beta-D-hexosaminidase. 4-Nitrophenyl-N-acetyl-β-D-glucosaminide is highly soluble and stable. 4-Nitrophenyl-N-acetyl-β-D-glucosaminide can be used for the study of renal tubular injury[1][2][3].

Product Specifications

CAS Number

[3459-18-5]

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/4-nitrophenyl-n-acetyl-β-d-glucosaminide.html

Purity

99.93

Solubility

DMSO : 40 mg/mL (ultrasonic; adjust pH to 2 with 1 M HCL) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(N[C@H]([C@H]([C@@H]([C@H](O1)CO)O)O)[C@@H]1OC2=CC=C(C=C2)[N+]([O-])=O)=O

Molecular Formula

C14H18N2O8

Molecular Weight

342.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Shibata H, et, al. Rate assay of N-acetyl-beta-D-hexosaminidase with 4-nitrophenyl N-acetyl-beta-D-glucosaminide as an artificial substrate. Clin Chim Acta. 1996 Jul 15;251 (1) :53-64. |[2]Skálová S, et al. The diagnostic role of urinary N-acetyl-beta-D-glucosaminidase (NAG) activity in the detection of renal tubular impairment. Acta Medica (Hradec Kralove) . 2005;48 (2) :75-80. |[3]Zou E, et al. Effects of hypoxia and sedimentary naphthalene on the activity of N-acetyl-beta-glucosaminidase in the epidermis of the brown shrimp, Penaeus aztecus. Bull Environ Contam Toxicol. 2009 May;82 (5) :579-82.