Nepodin

Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities.

Product Specifications

CAS Number

[3785-24-8]

Product Name Alternative

Musizin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

AMPK; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Epigenetics; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/nepodin.html

Purity

99.71

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC(C1=C(C)C=C2C=CC=C(O)C2=C1O)=O

Molecular Formula

C13H12O3

Molecular Weight

216.23

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee KH, et al. Antimalarial activity of nepodin isolated from Rumex crispus. Arch Pharm Res. 2013 Apr;36 (4) :430-5.|[2]Ha BG, et al. Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. Biofactors. 2014 Jul-Aug;40 (4) :436-47.