CD4, Ferret (HEK293, His)

CD4 Protein, an integral membrane glycoprotein, plays a pivotal role in immune responses. In T-cells, it serves as a coreceptor for MHC class II molecules, interacting with the T-cell receptor and initiating intracellular signaling pathways. In macrophages and NK cells, CD4 contributes to differentiation, cytokine expression, and cell migration independently of TCR/LCK. Additionally, CD4 is crucial in T-helper cell development, monocyte differentiation, and acts as the primary receptor for HIV-1, down-regulated by HIV-1 Vpu, and Human Herpesvirus 7/HHV-7. CD4 Protein, Ferret (HEK293, His) is the recombinant CD4 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD4 Protein, Ferret (HEK293, His) is 376 a.a., with molecular weight of ~52 kDa.

REVVLGKVG DTAELPCNGS VGQNIVFNWM QSTVKILGRQ INFWITGASK LKNRVESKKN LWDQGSFPLI IKNLEAADSG VYFCEVDGKK QAVELLVFNL TAKWNTGSSS GGSNIRLLQG QQLTLTVEAP SGSSPSVQWK GPGNKSKGSG HRLSLSGLDV QESGTWTCTI SQNQKTVVFN INILVLGFQK VSNTVYSREG EQVKFSFPLN FEIEKLSGEL RWRTEGAPSS LLWSSFTLEN KKLFVKEVHH PRLQLKETLP LSFILPQASS QYAGSGTLTL SLAKGTLQQE VNLVVMRVTK FTNNLTCEVM GPTSPELTLS LNLEERAAKV SKQQKLVSVV EPEDGTWQCL LSDKDKVLLA SKVEVLSPVF TKAWPKL