XST-14
Product Specifications
UNSPSC Description
XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects[1].
Target Antigen
Anaplastic lymphoma kinase (ALK); Apoptosis; CaMK; p38 MAPK; TGF-β Receptor; ULK
Type
Reference compound
Related Pathways
Apoptosis;Autophagy;MAPK/ERK Pathway;Neuronal Signaling;Protein Tyrosine Kinase/RTK;TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xst-14.html
Smiles
O=C(OC)C1=CC2=C(OC(C)C)C=C(OC(C)C)C=C2N1
Molecular Weight
291.34
References & Citations
[1]Si-Tu Xue, et al. The role of the key autophagy kinase ULK1 in hepatocellular carcinoma and its validation as a treatment target . Autophagy. 2020 Oct;16(10):1823-1837.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-137506/XST-14-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-137506/XST-14-SDS-MedChemExpress.pdf
CAS Number
2607143-50-8
Available Sizes
Curated Selection
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