XST-14

XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects[1].

Product Specifications

CAS Number

[2607143-50-8]

UNSPSC

12352005

Target

Anaplastic lymphoma kinase (ALK) ; Apoptosis; CaMK; p38 MAPK; TGF-β Receptor; ULK

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; MAPK/ERK Pathway; Neuronal Signaling; Protein Tyrosine Kinase/RTK; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/xst-14.html

Purity

99.26

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(OC)C1=CC2=C(OC(C)C)C=C(OC(C)C)C=C2N1

Molecular Formula

C16H21NO4

Molecular Weight

291.34

References & Citations

[1]Si-Tu Xue, et al. The role of the key autophagy kinase ULK1 in hepatocellular carcinoma and its validation as a treatment target . Autophagy. 2020 Oct;16 (10) :1823-1837.