CyPPA

CyPPA is a positive modulator of hSK3 and hSK2, with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA is inactive on both hSK1 and hIK channels[1][2].

Product Specifications

CAS Number

[73029-73-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cyppa.html

Concentration

10mM

Purity

99.71

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC(NC2CCCCC2)=NC(N3N=C(C)C=C3C)=N1

Molecular Formula

C16H23N5

Molecular Weight

285.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. Br J Pharmacol. 2007 Jul;151 (5) :655-65.|[2]Dana V Skarra, et al. CyPPA, a positive modulator of small-conductance Ca (2+) -activated K (+) channels, inhibits phasic uterine contractions and delays preterm birth in mice. Am J Physiol Cell Physiol. 2011 Nov;301 (5) :C1027-35.