Purmorphamine
Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM.
Product Specifications
CAS Number
483367-10-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Organoid; Smo
Type
Reference compound
Related Pathways
Autophagy; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Purmorphamine.html
Purity
99.9
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
N1(C2=CC=C(NC3=NC(OC4=CC=CC5=C4C=CC=C5)=NC6=C3N=CN6C7CCCCC7)C=C2)CCOCC1
Molecular Formula
C31H32N6O2
Molecular Weight
520.62
Precautions
H302, H315, H319, H335
References & Citations
[1]Beloti MM, et al. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell Biol Int. 2005 Jul;29 (7) :537-41.. . . .|[2]Gu D, et al. A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis. J Biol Chem. 2012 Nov 2;287 (45) :38356-66.|[3]Beloti MM, et al. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell Biol Int. 2005 Jul;29 (7) :537-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Adv Sci (Weinh) . 2025 May;12 (17) :e2411235.|Am J Physiol Cell Physiol. 2025 Oct 8.|Arthritis Res Ther. 2024 Jan 25;26 (1) :36.|Biochem Biophys Res Commun. 2021 Oct 15:574:1-7.|Burns Trauma. 2019 Sep 23;7:29.|Cancer Med. 2018 Nov;7 (11) :5704-5715.|Cell. 2025 Jun 26;188 (13) :3441-3458.e25.|Int J Mol Sci. 2024 Apr 9, 25 (8), 4138.|J Exp Clin Cancer Res. 2018 Nov 27;37 (1) :287. |J Hazard Mater. 2025 Oct 17:499:140149.|Med Oncol. 2021 Mar 17;38 (4) :41.|Mil Med Res. 2020 Nov 1;7 (1) :52.|Mil Med Res. 2020 Sep 6;7 (1) :42.|Mol Cell Toxicol. 2025 Oct 23.|Oncol Lett. 2019 Sep;18 (3) :3081-3091.|Patent. US20180263995A1.|Pharmacol Res. 2021 Mar:165:105460.|Res Sq. 2025 Apr 24.|Transl Neurodegener. 2024 Oct 29;13 (1) :53.|Life Sci. 2023 Sep 15:329:121990.
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