UNC0379 (TFA)
Product Specifications
UNSPSC Description
UNC0379 TFA is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 (KMT5A) with an IC50 of 7.3 μM, KD value of 18.3 μM. UNC0379 TFA can be used in the research of inflammation and cancers, such as pulmonary fibrosis, ovarian cancer, neuroblastoma[1][2][3].
Target Antigen
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/UNC0379-trifluoroacetate.html
Purity
99.91
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
COC1=C(OC)C=C2C(N=C(N3CCCC3)N=C2NCCCCCN4CCCC4)=C1.O=C(O)C(F)(F)F
Molecular Weight
527.58
References & Citations
[1]Ma A, et al. Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8. J Med Chem. 2014 Aug 14;57(15):6822-33.|[2]Miku Wada, et al. Epigenetic Modifier SETD8 as a Therapeutic Target for High-Grade Serous Ovarian Cancer. Biomolecules. 2020 Dec 16;10(12):1686. |[3]Keita Ugai, et al. Inhibition of the SET8 Pathway Ameliorates Lung Fibrosis Even Through Fibroblast Dedifferentiation. Front Mol Biosci. 2020 Aug 5;7:192.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12335A/UNC0379-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12335A/UNC0379-TFA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1620401-83-3
Available Sizes
Curated Selection
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