1-Deoxynojirimycin
1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features[1][2].
Product Specifications
CAS Number
19130-96-2
Product Name Alternative
Duvoglustat
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Glycosidase; PI3K
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/1-Deoxynojirimycin.html
Purity
99.94
Solubility
H2O : 125 mg/mL (ultrasonic)
Smiles
O[C@@H]1[C@@H](CO)NC[C@H](O)[C@H]1O
Molecular Formula
C6H13NO4
Molecular Weight
163.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Chaluntorn Vichasilp, et al. Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction. LWT - Food Science and Technology. Volume 45, Issue 2, March 2012, Pages 226-232|[2]Gao K, et al. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing. Molecules. 2016 Nov 23;21 (11) . pii: E1600.|[3]Liu Q, et al. 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice. Molecules. 2015 Dec 4;20 (12) :21700-14.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 3
Available Sizes
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