1-Deoxynojirimycin

1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features[1][2].

Product Specifications

CAS Number

[19130-96-2]

Product Name Alternative

Duvoglustat

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Glycosidase; PI3K

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/1-Deoxynojirimycin.html

Purity

99.94

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@@H](CO)NC[C@H](O)[C@H]1O

Molecular Formula

C6H13NO4

Molecular Weight

163.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Chaluntorn Vichasilp, et al. Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction. LWT - Food Science and Technology. Volume 45, Issue 2, March 2012, Pages 226-232|[2]Gao K, et al. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing. Molecules. 2016 Nov 23;21 (11) . pii: E1600.|[3]Liu Q, et al. 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice. Molecules. 2015 Dec 4;20 (12) :21700-14.