Nur77 modulator 1

Nur77 modulator 1 is a good Nur77 binder (KD = 3.58 μM) . Nur77 modulator 1 up-regulates Nur77 expression, mediates sub-cellular localization of Nur77, induces Nur77-dependent ER stress and autophagy, and results in cell apoptosis. Anti-hepatoma activity[1].

Product Specifications

CAS Number

[2469975-55-9]

UNSPSC

12352005

Hazard Statement

H302, H312, H315, H319, H332, H335

Target

Apoptosis; Nuclear Hormone Receptor 4A/NR4A

Type

Reference compound

Related Pathways

Apoptosis; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nur77-modulator-1.html

Purity

98.61

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC1=NC2=C(OC)C=CC=C2C(NC3=CC4=C(NC(C(N/N=C/C5=CC=C(SC)C=C5)=O)=C4)C=C3)=C1

Molecular Formula

C28H25N5O2S

Molecular Weight

495.60

Precautions

H302, H312, H315, H319, H332, H335

References & Citations

[1]Baicun Li, et al. Design, synthesis, and biological evaluation of 5- ((8-methoxy-2-methylquinolin-4-yl) amino) -1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators. Eur J Med Chem. 2020 Oct 15;204:112608.