Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Brexpiprazole S-oxide

Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4) . Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].

Product Specifications

CAS Number

1191900-51-2

Product Name Alternative

DM-3411

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/brexpiprazole-s-oxide.html

Purity

96.19

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1NC2=C(C=CC(OCCCCN3CCN(C4=C(C=CS5=O)C5=CC=C4)CC3)=C2)C=C1

Molecular Formula

C25H27N3O3S

Molecular Weight

449.57

References & Citations

[1]Chen B, et al. Effects of 26 Recombinant CYP3A4 Variants on Brexpiprazole Metabolism. Chem Res Toxicol. 2019 Oct 17.|[2]Ishima T, et al. Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors. Eur Neuropsychopharmacol. 2015 Apr;25 (4) :505-11.|[3]Yoshimi N, et al. Improvement of dizocilpine-induced social recognition deficits in mice by brexpiprazole, a novel serotonin-dopamine activity modulator. Eur Neuropsychopharmacol. 2015 Mar;25 (3) :356-64.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT1 Receptor;5-HT2 Receptor; D2 Receptor; mLAG-3; α-1 microglobulin

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Human GAL3 (Galectin 3) CLIA Kit
E-CL-H0948-01 24 Tests

Human GAL3 (Galectin 3) CLIA Kit

Sign In for Pricing
View Details
Human GAL3 (Galectin 3) CLIA Kit
E-CL-H0948-02 48 Tests

Human GAL3 (Galectin 3) CLIA Kit

Sign In for Pricing
View Details
Human GAL3 (Galectin 3) CLIA Kit
E-CL-H0948-03 96 Tests

Human GAL3 (Galectin 3) CLIA Kit

Sign In for Pricing
View Details
SSH3 Rabbit Polyclonal Antibody
TA362328 100 µL

SSH3 Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
CHCHD10 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3D7]
TA811808AM 100 µL

CHCHD10 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3D7]

Sign In for Pricing
View Details
PRAS40 (AKT1S1) (NM_001098632) Human Over-expression Lysate
LC420655 20 µg

PRAS40 (AKT1S1) (NM_001098632) Human Over-expression Lysate

Sign In for Pricing
View Details