MMP2-IN-3
MMP2-IN-3 (compound 2) is a potent MMP-2 (matrix metalloproteinases) inhibitor, with an IC50 of 31 μM. MMP2-IN-3 also shows inhibitory activity against MMP-9 and MMP-8, with IC50 values of 26.6, and 32 μM, respectively[1].
Product Specifications
CAS Number
897799-81-4
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mmp2-in-3.html
Purity
99.64
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC=C2N=C(NC2=C1)C3=CC=CC(NC(CCC4=CC=CC=C4)=O)=C3
Molecular Formula
C23H21N3O
Molecular Weight
355.43
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Laghezza A, et al. Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. Bioorg Med Chem. 2020 Feb 1;28 (3) :115257.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-13; MMP-2; MMP-8; MMP-9
Available Sizes
Frequently Asked Questions
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