MMP2-IN-3

MMP2-IN-3 (compound 2) is a potent MMP-2 (matrix metalloproteinases) inhibitor, with an IC50 of 31 μM. MMP2-IN-3 also shows inhibitory activity against MMP-9 and MMP-8, with IC50 values of 26.6, and 32 μM, respectively[1].

Product Specifications

CAS Number

[897799-81-4]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mmp2-in-3.html

Purity

99.64

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC=C2N=C(NC2=C1)C3=CC=CC(NC(CCC4=CC=CC=C4)=O)=C3

Molecular Formula

C23H21N3O

Molecular Weight

355.43

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Laghezza A, et al. Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. Bioorg Med Chem. 2020 Feb 1;28 (3) :115257.