Bisaramil (hydrochloride)

Bisaramil hydrochloride is an antiarrhythmic compound with activity in inhibiting free radical generation. Bisaramil hydrochloride directly blocks sodium currents and exhibits enhanced sodium channel blocking ability. Bisaramil hydrochloride inhibits isoproterenol-induced slow calcium action potentials in cardiomyocytes. Bisaramil hydrochloride reduces heart rate and prolongs the PR, QRS, and QT intervals in the electrocardiogram, showing blocking effects on sodium and potassium channels. Bisaramil hydrochloride reduces cardiac conduction velocity, increases the threshold current for capture and atrial fibrillation, and prolongs the effective refractory period. Bisaramil hydrochloride reduces ventricular arrhythmias and eliminates mortality caused by ventricular fibrillation in ischemic rat hearts[1].

Product Specifications

CAS Number

[96480-44-3]

UNSPSC

12352005

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bisaramil-hydrochloride.html

Smiles

O=C(C1=CC=C(Cl)C=C1)O[C@]2([C@H]3CN(CC)C[C@@H]2CN(C)C3)[H].Cl

Molecular Formula

C17H24Cl2N2O2

Molecular Weight

359.29

References & Citations

[1]M K Pugsley, et al. Effects of bisaramil, a novel class I antiarrhythmic agent, on heart, skeletal muscle and brain Na+ channels. Eur J Pharmacol. 1998 Jan 19;342 (1) :93-104.|[2]M Paróczai, et al. Bisaramil and antiarrhythmics as inhibitors of free radical generation. Pharmacol Res. 1997 Apr;35 (4) :279-85.|[3]The antiarrhythmic actions of bisaramil and penticainide result from mixed cardiac ion channel blockade