TET-13
TET-13 is a positive allosteric modulator of GABAA receptor with an EC50 of 5.65 μM, lower than that of Etomidate (EC50: 9.29 μM) . TET-13 shows potent anesthetic effects in both mice and rats (ED50: 0.48 mg/kg and 0.69 mg/kg, respectively) [1].
Product Specifications
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tet-13.html
Smiles
COC(CSC(C1=CN=CN1[C@H](C)C2=CC=CC=C2)=O)=O
Molecular Formula
C15H16N2O3S
Molecular Weight
304.36
References & Citations
[1]Zhu, et al. Discovery of thioetomidate derivatives as rapid recovery hypnotics without adrenocortical suppression. Bioorganic chemistry. 2024, 154, 107997.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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