SCH900776
SCH900776 (MK-8776) is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with an IC50 of 3 nM. SCH900776 shows 50- and 500-fold selectivity over CDK2 and Chk2, respectively[1][2].
Product Specifications
CAS Number
891494-63-6
Product Name Alternative
MK-8776
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SCH900776.html
Purity
99.97
Solubility
DMSO : ≥ 100 mg/mL
Smiles
NC1=C(Br)C([C@H]2CNCCC2)=NC3=C(C4=CN(C)N=C4)C=NN13
Molecular Formula
C15H18BrN7
Molecular Weight
376.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Montano R, et al. Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites. Mol Cancer Ther. 2012 Feb;11 (2) :427-38.|[2]Guzi TJ, et al. Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. Mol Cancer Ther. 2011 Apr;10 (4) :591-602.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Chk1; Chk2
Available Sizes
Frequently Asked Questions
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