SCH900776

SCH900776 (MK-8776) is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with an IC50 of 3 nM. SCH900776 shows 50- and 500-fold selectivity over CDK2 and Chk2, respectively[1][2].

Product Specifications

CAS Number

[891494-63-6]

Product Name Alternative

MK-8776

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Checkpoint Kinase (Chk)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SCH900776.html

Purity

99.97

Solubility

DMSO : ≥ 100 mg/mL

Smiles

NC1=C(Br)C([C@H]2CNCCC2)=NC3=C(C4=CN(C)N=C4)C=NN13

Molecular Formula

C15H18BrN7

Molecular Weight

376.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Montano R, et al. Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites. Mol Cancer Ther. 2012 Feb;11 (2) :427-38.|[2]Guzi TJ, et al. Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. Mol Cancer Ther. 2011 Apr;10 (4) :591-602.