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Stearoyl-L-carnitine-d3

Stearoyl-L-carnitine-d3 is the deuterium labeled Stearoylcarnitine. Stearoylcarnitine, a fatty ester lipid molecule, is an endogenous metabolite. Stearoylcarnitine can be used as PKC inhibitor. Stearoylcarnitine accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoylcarnitine inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoylcarnitine acts as a metabolomics biomarker for Parkinson’s disease. Stearoylcarnitine is a less potent inhibitor of GlyT2[1][2][3][4][5][6][7].

Product Specifications

CAS Number

1021439-31-5

Product Name Alternative

5-(4-Phenoxybutoxy)psoralen

UNSPSC

12352211

Target

Endogenous Metabolite; GlyT; Isotope-Labeled Compounds; PKC

Type

Isotope-Labeled Compounds

Related Pathways

Epigenetics; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others; TGF-beta/Smad

Field of Research

Metabolic Disease; Neurological Disease

Solubility

10 mM in DMSO

Smiles

CCCCCCCCCCCCCCCCCC(O[C@H](CC([O-])=O)C[N+](C)(C([2H])([2H])[2H])C)=O

Molecular Formula

C25H46D3NO4

Molecular Weight

430.68

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Maria P H Koster, et al. First-Trimester Serum Acylcarnitine Levels to Predict Preeclampsia: A Metabolomics Approach. Dis Markers. 2015;2015:857108.|[3]Aichler M, et al. N-acyl Taurines and Acylcarnitines Cause an Imbalance in Insulin Synthesis and Secretion Provoking β Cell Dysfunction in Type 2 Diabetes. Cell Metab. 2017 Jun 6;25 (6) :1334-1347.e4.|[4]Dave AM, et al. Neonatal Hypoxic-Ischemic Brain Injury Alters Brain Acylcarnitine Levels in a Mouse Model. Metabolites. 2022 May 22;12 (5) :467.|[5]Bell FP. Carnitine esters: novel inhibitors of plasma lecithin: cholesterol acyltransferase in experimental animals but not in man (Homo sapiens) . Int J Biochem. 1983;15 (2) :133-6.|[6]Li XZ, et al. Cerebral metabonomics study on Parkinson's disease mice treated with extract of Acanthopanax senticosus harms. Phytomedicine. 2013 Oct 15;20 (13) :1219-29.|[7]da Luz G, et al. Triterpene derivative: A potential signaling pathway for the fern-9 (11) -ene-2α,3β-diol on insulin secretion in pancreatic islet. Life Sci. 2016 Jun 1;154:58-65.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

Phase 2

Available Sizes

Frequently Asked Questions

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