αA-Conotoxin OIVA

αA-Conotoxin OIVA (αA-OIVA) is a selective nAChR antagonist with an IC50 of 56 nM against mammalian fetal muscle nAChR. αA-Conotoxin OIVA is a peptide that can be derived from conotoxin. αA-Conotoxin OIVA paralyzes muscles[1][2].

O=C1N2[C@](C[C@H](C2)O)([H])C(N[C@]3([H])C(N[C@H](C(N[C@](CSSC[C@]4([H])NC([C@H](CSSC[C@@](NC([C@@H](NC([C@@H](NC([C@@H](NC(C5([H])N(C[C@@H](C5)O)C([C@@H](NC(CNC4=O)=O)C(C)C)=O)=O)CC(N)=O)=O)C)=O)C)=O)([H])C(N[C@H]1CC6=CN=CN6)=O)N)=O)([H])C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@@H](CSSC3)C(N)=O)=O)([H])[C@H](O)C)=O)CC(N)=O)=O)CCCCN)=O)=O)C(C)C)=O)=O

[1]Teichert RW, et al. A uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor. J Neurosci. 2005 Jan 19;25(3):732-6.|[2]Teichert RW, et al. AlphaA-Conotoxin OIVA defines a new alphaA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors. Toxicon. 2004 Aug;44(2):207-14.