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NSC 146109 (hydrochloride)

NSC 146109 hydrochloride is a small-molecule p53 activator that target MDMX and can be used for breast cancer research. NSC 146109 hydrochloride is a pseudourea derivative, promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes[1].

Product Specifications

CAS Number

59474-01-0

UNSPSC

12352005

Hazard Statement

H300

Target

Apoptosis; MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nsc-146109-hydrochloride.html

Purity

99.60

Solubility

DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[H]Cl.NC(SCC1=C2C=CC=CC2=C(C)C3=CC=CC=C13)=N

Molecular Formula

C17H17ClN2S

Molecular Weight

316.85

Precautions

H300

References & Citations

[1]Wang H, et al. A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells. Neoplasia. 2011 Jul;13 (7) :611-9.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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