NSC 146109 (hydrochloride)
NSC 146109 hydrochloride is a small-molecule p53 activator that target MDMX and can be used for breast cancer research. NSC 146109 hydrochloride is a pseudourea derivative, promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes[1].
Product Specifications
CAS Number
59474-01-0
UNSPSC
12352005
Hazard Statement
H300
Target
Apoptosis; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc-146109-hydrochloride.html
Purity
99.60
Solubility
DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
[H]Cl.NC(SCC1=C2C=CC=CC2=C(C)C3=CC=CC=C13)=N
Molecular Formula
C17H17ClN2S
Molecular Weight
316.85
Precautions
H300
References & Citations
[1]Wang H, et al. A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells. Neoplasia. 2011 Jul;13 (7) :611-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNUB2556-500 1x 500 µL
Spectrin Alpha 1 (Erythrocyte Marker) (rSPTA1/1833), 0.2mg/mL
Sign In for Pricing
View Details 
AP13678PU-N 400 µL
BCKDH kinase (BCKDK) (C-term) Rabbit Polyclonal Antibody
Sign In for Pricing
View Details 
