NSC 146109 (hydrochloride)
NSC 146109 hydrochloride is a small-molecule p53 activator that target MDMX and can be used for breast cancer research. NSC 146109 hydrochloride is a pseudourea derivative, promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes[1].
Product Specifications
CAS Number
59474-01-0
UNSPSC
12352005
Hazard Statement
H300
Target
Apoptosis; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc-146109-hydrochloride.html
Purity
99.60
Solubility
DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
[H]Cl.NC(SCC1=C2C=CC=CC2=C(C)C3=CC=CC=C13)=N
Molecular Formula
C17H17ClN2S
Molecular Weight
316.85
Precautions
H300
References & Citations
[1]Wang H, et al. A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells. Neoplasia. 2011 Jul;13 (7) :611-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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