Human Factor II (Prothrombin)

<strong>Human Factor II (Prothrombin)</strong>_x000D_ <strong>Catalog number:</strong> B2018746_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 9 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> N/A_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Downing MR, Butkowski RJ, Clark MM, Mann KG. Human prothrombin activation J Biol Chem. 1975 Dec 10;250(23):8897-906._x000D_ 2: Meddahi S, Bara L, Fessi H, Samama MM. Determination of prothombinase activation after adding human purified prothrombin to human clot: comparison of hirudin, an activated factor II inhibitor, with DX9065a, an activated factor X inhibitor, on clot-associated thrombin and on prothrombin activation Blood Coagul Fibrinolysis. 2005 Mar;16(2):125-33._x000D_ 3: Butenas S, van't Veer C, Mann KG. "Normal" thrombin generation Blood. 1999 Oct 1;94(7):2169-78._x000D_ 4: Di Scipio RG, Hermodson MA, Yates SG, Davie EW. A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein S Biochemistry. 1977 Feb 22;16(4):698-706._x000D_ 5: Zytkovicz TH, Nelsestuen GL. gamma-Carboxyglutamic acid distribution Biochim Biophys Acta. 1976 Sep 24;444(2):344-8._x000D_ 6: Di Paola J, Nugent D, Young G. Current therapy for rare factor deficiencies Haemophilia. 2001 Jan;7 Suppl 1:16-22._x000D_ 7: Kim HC, McMillan CW, White GC, Bergman GE, Horton MW, Saidi P. Purified factor IX using monoclonal immunoaffinity technique: clinical trials in hemophilia B and comparison to prothrombin complex concentrates Blood. 1992 Feb 1;79(3):568-75._x000D_ 8: Rosenberg JS, Beeler DL, Rosenberg RD. Activation of human prothrombin by highly purified human factors V and X-a in presence of human antithrombin J Biol Chem. 1975 Mar 10;250(5):1607-17._x000D_ 9: Nakagaki T, Lin P, Kisiel W. Activation of human factor VII by the prothrombin activator from the venom of Oxyuranus scutellatus (Taipan snake) Thromb Res. 1992 Jan 1;65(1):105-16._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/31420204">10: Shapiro A. The use of prophylaxis in the treatment of rare bleeding disorders Thromb Res. 2020 Dec;196:590-602. </a>_x000D_ _x000D_ <strong>Products Related to Human Factor II (Prothrombin) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>