Enarodustat

Enarodustat is a potent and orally active hypoxia-inducible factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM. Enarodustat has the potential for renal anemia treatment.

Product Specifications

CAS Number

[1262132-81-9]

Product Name Alternative

JTZ-951; SAL0951

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Enarodustat.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C(C(C1=NC=NN1C(CCC2=CC=CC=C2)=C3)=C3O)NCC(O)=O

Molecular Formula

C17H16N4O4

Molecular Weight

340.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Ogoshi Y, et al. Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia. ACS Med Chem Lett. 2017 Nov 20;8 (12) :1320-1325.