IPAG

IPAG is a potent sigma-1 receptor antagonist with a pKi of 4.3[1]. IPAG induces apoptosis[2].

Product Specifications

CAS Number

193527-91-2

UNSPSC

12352005

Hazard Statement

H410

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ipag.html

Purity

99.84

Solubility

DMSO : 8.33 mg/mL (ultrasonic; adjust pH to 3 with 1M HCl; heat to 60°C)

Smiles

N=C(NC1=CC=C(I)C=C1)NC2[C@H]3C[C@H](C4)C[C@@H]2C[C@H]4C3

Molecular Formula

C17H22IN3

Molecular Weight

395.28

Precautions

P273-P391-P501

References & Citations

[1]James M Brimson, et al. Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression. Sci Rep. 2020 Jun 8;10 (1) :9251.|[2]Halley M Oyer, et al.Small-Molecule Modulators of Sigma1 and Sigma2/TMEM97 in the Context of Cancer: Foundational Concepts and Emerging Themes. Front Pharmacol. 2019 Oct 21;10:1141.|[3]Felix J Kim, et al. Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem Biophys Res Commun. 2012 Sep 21;426 (2) :177-82.