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DC371739

DC371739 is a potent and orally activity PCSK9 inhibitor. DC371739 decreases the mRNA expression of PCSK9 and ANGPTL3. DC371739 decreases the protein expression of PCSK9 and increases the protein expression of LDLR. DC371739 has the potential for the research of hyperlipidemia[1][2].

Product Specifications

UNSPSC

12352005

Target

ANGPTL; PCSK9

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/dc371739.html

Purity

95.56

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

OCN1C2=C(C3=C1CN4CCC5=CC(OCC6=CC=CC=C6)=C(C=C5C4C3)OC)C=C(OC)C=C2

Molecular Formula

C29H30N2O4

Molecular Weight

470.56

References & Citations

[1]Bao X, et al. Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) : from bench to bedside. Signal Transduct Target Ther. 2024 Jan 8;9 (1) :13.|[2]Wang J, et al. Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial. Cell Metab. 2022 May 3;34 (5) :667-680.e6.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-163794/DC371739-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-163794/DC371739-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

Phase 1

CAS Number

[2135765-21-6]

Available Sizes

Curated Selection

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