Protosappanin A
Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3[1].
Product Specifications
CAS Number
102036-28-2
Product Name Alternative
PTA
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Interleukin Related; JAK; STAT
Type
Natural Products
Related Pathways
Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Protosappanin_A.html
Purity
99.95
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1CC2=CC(O)=C(O)C=C2C3=CC=C(O)C=C3OC1
Molecular Formula
C15H12O5
Molecular Weight
272.25
Precautions
H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
JAK2; STAT3
Available Sizes
Frequently Asked Questions
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