Protosappanin A

Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3[1].

Product Specifications

CAS Number

[102036-28-2]

Product Name Alternative

PTA

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Interleukin Related; JAK; STAT

Type

Natural Products

Related Pathways

Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Protosappanin_A.html

Purity

99.95

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1CC2=CC(O)=C(O)C=C2C3=CC=C(O)C=C3OC1

Molecular Formula

C15H12O5

Molecular Weight

272.25

Precautions

H315, H319

References & Citations

[1]Wang LC, et al. Protosappanin A exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Chin J Nat Med. 2017 Sep;15 (9) :674-679.|[2]Zeng KW, et al. Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia. Int Immunopharmacol, 2012, 14 (4) : 558- 569.