Protosappanin A
Product Specifications
UNSPSC Description
Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3[1].
Target Antigen
Interleukin Related; JAK; STAT
Type
Natural Products
Related Pathways
Epigenetics;Immunology/Inflammation;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Protosappanin_A.html
Purity
99.98
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1CC2=CC(O)=C(O)C=C2C3=CC=C(O)C=C3OC1
Molecular Weight
272.25
References & Citations
[1]Wang LC, et al. Protosappanin A exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Chin J Nat Med. 2017 Sep;15(9):674-679.|[2]Zeng KW, et al. Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia. Int Immunopharmacol, 2012, 14(4): 558- 569.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-113573/Protosappanin-A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-113573/Protosappanin-A-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
102036-28-2
Available Sizes
Curated Selection
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