Cisd2 agonist 1
Cisd2 agonist 1 (Compound 4q) is a Cisd2 agonist (EC50: 34 nM) . Cisd2 agonist 1 enhances the Cisd2 expression and improves the pathological changes in the fatty livers. Cisd2 agonist 1 has good metabolic stability. Cisd2 agonist 1 can be used for research of NAFLD[1].
Product Specifications
CAS Number
[2916371-54-3]
UNSPSC
12352005
Target
Mitophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cisd2-agonist-1.html
Concentration
10mM
Purity
99.22
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=C(C(OC)=O)C(C)=C(C(NC2=CC=C(C=C2)F)=O)S1
Molecular Formula
C14H13FN2O3S
Molecular Weight
308.33
References & Citations
[1]Yao CH, et al. Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease. Eur J Med Chem. 2023 Oct 5;258:115583.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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