SKA-111
SKA-111 is a selective activator of potassium phannel KCa 3.1 , evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell. SKA-111 is capable of improving Bradykinin (HY-P0206) -induced coronary dilations in the isolated rat heart and can be used for cardiovascular disease research[1].
Product Specifications
CAS Number
[1369170-24-0]
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ska-111.html
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC2=C3C=CC=CC3=C(C)C=C2S1
Molecular Formula
C12H10N2S
Molecular Weight
214.29
References & Citations
[1]Oliván-Viguera A, et.al. Vascular Reactivity Profile of Novel KCa 3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed. Basic Clin Pharmacol Toxicol. 2016 Aug;119 (2) :184-92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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