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SKA-111

SKA-111 is a selective activator of potassium phannel KCa 3.1 , evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell. SKA-111 is capable of improving Bradykinin -induced coronary dilations in the isolated rat heart and can be used for cardiovascular disease research[1].

Product Specifications

CAS Number

1369170-24-0

UNSPSC

12352005

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ska-111.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=NC2=C3C=CC=CC3=C(C)C=C2S1

Molecular Formula

C12H10N2S

Molecular Weight

214.29

References & Citations

[1]Oliván-Viguera A, et.al. Vascular Reactivity Profile of Novel KCa 3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed. Basic Clin Pharmacol Toxicol. 2016 Aug;119 (2) :184-92.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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